Haplotype Classification Using Copy Number Variation and Principal Components Analysis
نویسندگان
چکیده
منابع مشابه
Haplotype Classification Using Copy Number Variation and Principal Components Analysis
Elaborate downstream methods are required to analyze large microarray data-sets. At times, where the end goal is to look for relationships between (or patterns within) different subgroups or even just individual samples, large data-sets must first be filtered using statistical thresholds in order to reduce their overall volume. As an example, in anthropological microarray studies, such ‘dimensi...
متن کاملGenotype, haplotype and copy-number variation in worldwide human populations.
Genome-wide patterns of variation across individuals provide a powerful source of data for uncovering the history of migration, range expansion, and adaptation of the human species. However, high-resolution surveys of variation in genotype, haplotype and copy number have generally focused on a small number of population groups. Here we report the analysis of high-quality genotypes at 525,910 si...
متن کاملPersian Handwriting Analysis Using Functional Principal Components
Principal components analysis is a well-known statistical method in dealing with large dependent data sets. It is also used in functional data for both purposes of data reduction as well as variation representation. On the other hand "handwriting" is one of the objects, studied in various statistical fields like pattern recognition and shape analysis. Considering time as the argument,...
متن کاملAnalysis of copy number variation using quantitative interspecies competitive PCR
Over recent years small submicroscopic DNA copy-number variants (CNVs) have been highlighted as an important source of variation in the human genome, human phenotypic diversity and disease susceptibility. Consequently, there is a pressing need for the development of methods that allow the efficient, accurate and cheap measurement of genomic copy number polymorphisms in clinical cohorts. We have...
متن کاملBIRC5 Genomic Copy Number Variation in Early-Onset Breast Cancer
Background: Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5) gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. The copy number of BIRC5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood. Methods: Forty tumor tiss...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Open Bioinformatics Journal
سال: 2013
ISSN: 1875-0362
DOI: 10.2174/1875036201307010019